Disruption of Hepatic Mitochondrial Pyruvate and Amino Acid Metabolism Impairs Gluconeogenesis and Endurance Exercise Capacity in Mice

Exercise robustly increases the glucose demands of skeletal muscle. This demand is met not only by muscle glycogenolysis, but also by accelerated liver glucose production from hepatic glycogenolysis and gluconeogenesis to fuel mechanical work and prevent hypoglycemia during exercise. Hepatic glucone...

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Detalles Bibliográficos
Autores principales: Martino, Michael R., Habibi, Mohammad, Ferguson, Daniel, Brookheart, Rita T., Thyfault, John P., Meyer, Gretchen A., Lantier, Louise, Hughey, Curtis C., Finck, Brian N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473655/
https://www.ncbi.nlm.nih.gov/pubmed/37662392
http://dx.doi.org/10.1101/2023.08.22.554345

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473655/
https://www.ncbi.nlm.nih.gov/pubmed/37662392
http://dx.doi.org/10.1101/2023.08.22.554345

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