Disruption of Hepatic Mitochondrial Pyruvate and Amino Acid Metabolism Impairs Gluconeogenesis and Endurance Exercise Capacity in Mice

Exercise robustly increases the glucose demands of skeletal muscle. This demand is met not only by muscle glycogenolysis, but also by accelerated liver glucose production from hepatic glycogenolysis and gluconeogenesis to fuel mechanical work and prevent hypoglycemia during exercise. Hepatic glucone...

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Détails bibliographiques
Auteurs principaux: Martino, Michael R., Habibi, Mohammad, Ferguson, Daniel, Brookheart, Rita T., Thyfault, John P., Meyer, Gretchen A., Lantier, Louise, Hughey, Curtis C., Finck, Brian N.
Format: Online Article Texte
Langue:English
Publié: Cold Spring Harbor Laboratory 2023
Sujets:
Article
Accès en ligne:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473655/
https://www.ncbi.nlm.nih.gov/pubmed/37662392
http://dx.doi.org/10.1101/2023.08.22.554345

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473655/
https://www.ncbi.nlm.nih.gov/pubmed/37662392
http://dx.doi.org/10.1101/2023.08.22.554345

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