De novo design of buttressed loops for sculpting protein functions

In natural proteins, structured loops play central roles in molecular recognition, signal transduction and enzyme catalysis. However, because of the intrinsic flexibility and irregularity of loop regions, organizing multiple structured loops at protein functional sites has been very difficult to ach...

Descripción completa

Detalles Bibliográficos
Autores principales: Jiang, Hanlun, Jude, Kevin M., Wu, Kejia, Fallas, Jorge, Ueda, George, Brunette, TJ, Hicks, Derrick, Pyles, Harley, Yang, Aerin, Carter, Lauren, Lamb, Mila, Li, Xinting, Levine, Paul M., Stewart, Lance, Garcia, K. Christopher, Baker, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473674/
https://www.ncbi.nlm.nih.gov/pubmed/37662224
http://dx.doi.org/10.1101/2023.08.22.554384

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473674/
https://www.ncbi.nlm.nih.gov/pubmed/37662224
http://dx.doi.org/10.1101/2023.08.22.554384

Ejemplares similares