Human plasma cells engineered to secrete bispecifics drive effective in vivo leukemia killing

Bispecific antibodies are an important tool for the management and treatment of acute leukemias. Advances in genome-engineering have enabled the generation of human plasma cells that secrete therapeutic proteins and are capable of long-term in vivo engraftment in humanized mouse models. As a next st...

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Detalles Bibliográficos
Autores principales: Hill, Tyler F., Narvekar, Parnal, Asher, Gregory, Camp, Nathan, Thomas, Kerri R., Tasian, Sarah K., Rawlings, David J., James, Richard G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473709/
https://www.ncbi.nlm.nih.gov/pubmed/37662410
http://dx.doi.org/10.1101/2023.08.24.554523

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473709/
https://www.ncbi.nlm.nih.gov/pubmed/37662410
http://dx.doi.org/10.1101/2023.08.24.554523

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