Caloric restriction promotes beta cell longevity and delays aging and senescence by enhancing cell identity and homeostasis mechanisms

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Caloric restriction (CR) extends organismal lifespan and health span by improving glucose homeostasis mechanisms. How CR affects organellar structure and function of pancreatic beta cells over the lifetime of the animal remains unknown. Here, we used single nucleus transcriptomics to show that CR in...

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Detalles Bibliográficos
Autores principales: dos Santos, Cristiane, Shrestha, Shristi, Cottam, Matthew, Perkins, Guy, Lev-Ram, Varda, Roy, Birbickram, Acree, Christopher, Kim, Keun-Young, Deerinck, Thomas, Cutler, Melanie, Dean, Danielle, Cartailler, Jean Philippe, MacDonald, Patrick E., Hetzer, Martin, Ellisman, Mark, e Drigo, Rafael Arrojo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473730/
https://www.ncbi.nlm.nih.gov/pubmed/37662336
http://dx.doi.org/10.1101/2023.08.23.554369

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473730/
https://www.ncbi.nlm.nih.gov/pubmed/37662336
http://dx.doi.org/10.1101/2023.08.23.554369

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