α-Synuclein emulsifies TDP-43 prion-like domain – RNA liquid droplets to promote heterotypic amyloid fibrils

Many neurodegenerative diseases including frontotemporal lobar degeneration (FTLD), Lewy body disease (LBD), multiple system atrophy (MSA), etc., show colocalized deposits of TDP-43 and α-synuclein (αS) aggregates. To understand whether these colocalizations are driven by specific molecular interact...

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Detalles Bibliográficos
Autores principales: Dhakal, Shailendra, Mondal, Malay, Mirzazadeh, Azin, Banerjee, Siddhartha, Ghosh, Ayanjeet, Rangachari, Vijayaraghavan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473755/
https://www.ncbi.nlm.nih.gov/pubmed/37662377
http://dx.doi.org/10.1101/2023.08.23.554502

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473755/
https://www.ncbi.nlm.nih.gov/pubmed/37662377
http://dx.doi.org/10.1101/2023.08.23.554502

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