Divergent Pairwise Epistasis in the Context of Unstable Membrane Protein Variants

Many eukaryotic membrane proteins are prone to misfolding, which compromises their functional expression at the plasma membrane. This is particularly true for mammalian gonadotropin-releasing hormone receptors (GnRHRs), which are G protein-coupled receptors involved in reproductive steroidogenesis....

Descripción completa

Detalles Bibliográficos
Autores principales: Chamness, Laura M., Kuntz, Charles P., McKee, Andrew G., Penn, Wesley D., Hemmerich, Christopher M., Rusch, Douglas B., Woods, Hope, Dyotima, Meiler, Jens, Schlebach, Jonathan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473758/
https://www.ncbi.nlm.nih.gov/pubmed/37662415
http://dx.doi.org/10.1101/2023.08.25.554866

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473758/
https://www.ncbi.nlm.nih.gov/pubmed/37662415
http://dx.doi.org/10.1101/2023.08.25.554866

Ejemplares similares