Clinical consequences of a polygenic predisposition to benign lower white blood cell counts: Consequences of benign WBC count genetics

Polygenic variation unrelated to disease contributes to interindividual variation in baseline white blood cell (WBC) counts, but its clinical significance is undefined. We investigated the clinical consequences of a genetic predisposition toward lower WBC counts among 89,559 biobank participants fro...

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Detalles Bibliográficos
Autores principales: Mosley, Jonathan D., Shelley, John P., Dickson, Alyson L., Zanussi, Jacy, Daniel, Laura L., Zheng, Neil S., Bastarache, Lisa, Wei, Wei-Qi, Shi, Mingjian, Jarvik, Gail P., Rosenthal, Elisabeth A., Khan, Atlas, Sherafati, Alborz, Kullo, Iftikhar J., Walunas, Theresa L., Glessner, Joe, Hakonarson, Hakon, Cox, Nancy J., Roden, Dan M., Frangakis, Stephan G., Vanderwerff, Brett, Stein, C. Michael, Van Driest, Sara L., Borinstein, Scott C., Shu, Xiao-Ou, Zawistowski, Matthew, Chung, Cecilia P., Kawai, Vivian K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473820/
https://www.ncbi.nlm.nih.gov/pubmed/37662324
http://dx.doi.org/10.1101/2023.08.20.23294331

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473820/
https://www.ncbi.nlm.nih.gov/pubmed/37662324
http://dx.doi.org/10.1101/2023.08.20.23294331

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