Suppression of alpha-carbon racemization in peptide synthesis based on a thiol-labile amino protecting group

In conventional solid-phase peptide synthesis (SPPS), α-amino groups are protected with alkoxycarbonyl groups (e.g., 9-fluorenylmethoxycarbonyl [Fmoc]). However, during SPPS, inherent side reactions of the protected amino acids (e.g., α-C racemization and aspartimide formation) generate by-products...

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Detalles Bibliográficos
Autores principales: Zhou, Yifei, Li, Hongjun, Huang, Yi, Li, Jiahui, Deng, Guiyu, Chen, Gong, Xi, Zhen, Zhou, Chuanzheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10474026/
https://www.ncbi.nlm.nih.gov/pubmed/37658053
http://dx.doi.org/10.1038/s41467-023-41115-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10474026/
https://www.ncbi.nlm.nih.gov/pubmed/37658053
http://dx.doi.org/10.1038/s41467-023-41115-x

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