Acquired miR-142 deficit in leukemic stem cells suffices to drive chronic myeloid leukemia into blast crisis

The mechanisms underlying the transformation of chronic myeloid leukemia (CML) from chronic phase (CP) to blast crisis (BC) are not fully elucidated. Here, we show lower levels of miR-142 in CD34(+)CD38(−) blasts from BC CML patients than in those from CP CML patients, suggesting that miR-142 defici...

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Detalles Bibliográficos
Autores principales: Zhang, Bin, Zhao, Dandan, Chen, Fang, Frankhouser, David, Wang, Huafeng, Pathak, Khyatiben V., Dong, Lei, Torres, Anakaren, Garcia-Mansfield, Krystine, Zhang, Yi, Hoang, Dinh Hoa, Chen, Min-Hsuan, Tao, Shu, Cho, Hyejin, Liang, Yong, Perrotti, Danilo, Branciamore, Sergio, Rockne, Russell, Wu, Xiwei, Ghoda, Lucy, Li, Ling, Jin, Jie, Chen, Jianjun, Yu, Jianhua, Caligiuri, Michael A., Kuo, Ya-Huei, Boldin, Mark, Su, Rui, Swiderski, Piotr, Kortylewski, Marcin, Pirrotte, Patrick, Nguyen, Le Xuan Truong, Marcucci, Guido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10474062/
https://www.ncbi.nlm.nih.gov/pubmed/37658085
http://dx.doi.org/10.1038/s41467-023-41167-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10474062/
https://www.ncbi.nlm.nih.gov/pubmed/37658085
http://dx.doi.org/10.1038/s41467-023-41167-z

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