A detailed kinetic model of glycolysis in Plasmodium falciparum-infected red blood cells for antimalarial drug target identification

Upon infection by the malaria parasite Plasmodium falciparum, the glycolytic rate of a red blood cell increases up to 100-fold, possibly contributing to lactic acidosis and hypoglycemia in patients with severe malaria. This dramatic increase in glucose uptake and metabolism was correctly predicted b...

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Detalles Bibliográficos
Autores principales: van Niekerk, David D., du Toit, Francois, Green, Kathleen, Palm, Danie, Snoep, Jacky L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10474083/
https://www.ncbi.nlm.nih.gov/pubmed/37517694
http://dx.doi.org/10.1016/j.jbc.2023.105111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10474083/
https://www.ncbi.nlm.nih.gov/pubmed/37517694
http://dx.doi.org/10.1016/j.jbc.2023.105111

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