TGR5 supresses cGAS/STING pathway by inhibiting GRP75-mediated endoplasmic reticulum-mitochondrial coupling in diabetic retinopathy

Diabetic retinopathy (DR) is a serious and relatively under-recognized complication of diabetes. Müller glial cells extend throughout the retina and play vital roles in maintaining retinal homeostasis. Previous studies have demonstrated that TGR5, a member of the bile acid-activated GPCR family, cou...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Yan, Zhu, Lingpeng, Cai, Meng-Xia, Wang, Zi-Li, Zhuang, Miao, Tan, Cheng-Ye, Xie, Tian-Hua, Yao, Yong, Wei, Ting-Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10474119/
https://www.ncbi.nlm.nih.gov/pubmed/37658045
http://dx.doi.org/10.1038/s41419-023-06111-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10474119/
https://www.ncbi.nlm.nih.gov/pubmed/37658045
http://dx.doi.org/10.1038/s41419-023-06111-5

Ejemplares similares