Germline pathogenic variants in HNRNPU are associated with alterations in blood methylome

HNRNPU encodes a multifunctional RNA-binding protein that plays critical roles in regulating pre-mRNA splicing, mRNA stability, and translation. Aberrant expression and dysregulation of HNRNPU have been implicated in various human diseases, including cancers and neurological disorders. We applied a...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Sunwoo, Ochoa, Eguzkine, Badura-Stronka, Magdalena, Donnelly, Deirdre, Lederer, Damien, Lynch, Sally A., Gardham, Alice, Morton, Jenny, Stewart, Helen, Docquier, France, Rodger, Fay, Martin, Ezequiel, Toribio, Ana, Maher, Eamonn R., Balasubramanian, Meena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10474128/
https://www.ncbi.nlm.nih.gov/pubmed/37407733
http://dx.doi.org/10.1038/s41431-023-01422-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10474128/
https://www.ncbi.nlm.nih.gov/pubmed/37407733
http://dx.doi.org/10.1038/s41431-023-01422-9

Ejemplares similares