The transcription factor NRF1 (NFE2L1) activates aggrephagy by inducing p62 and GABARAPL1 after proteasome inhibition to maintain proteostasis

The ubiquitin‒proteasome system (UPS) and autophagy are the two primary cellular pathways of misfolded or damaged protein degradation that maintain cellular proteostasis. When the proteasome is dysfunctional, cells compensate for impaired protein clearance by activating aggrephagy, a type of selecti...

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Detalles Bibliográficos
Autores principales: Hatanaka, Atsushi, Nakada, Sota, Matsumoto, Gen, Satoh, Katsuya, Aketa, Iori, Watanabe, Akira, Hirakawa, Tomoaki, Tsujita, Tadayuki, Waku, Tsuyoshi, Kobayashi, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10474156/
https://www.ncbi.nlm.nih.gov/pubmed/37658135
http://dx.doi.org/10.1038/s41598-023-41492-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10474156/
https://www.ncbi.nlm.nih.gov/pubmed/37658135
http://dx.doi.org/10.1038/s41598-023-41492-9

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