Reversal of dual epigenetic repression of non-canonical Wnt-5a normalises diabetic corneal epithelial wound healing and stem cells

AIMS/HYPOTHESIS: Diabetes is associated with epigenetic modifications including DNA methylation and miRNA changes. Diabetic complications in the cornea can cause persistent epithelial defects and impaired wound healing due to limbal epithelial stem cell (LESC) dysfunction. In this study, we aimed to...

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Detalles Bibliográficos
Autores principales: Shah, Ruchi, Spektor, Tanya M., Weisenberger, Daniel J., Ding, Hui, Patil, Rameshwar, Amador, Cynthia, Song, Xue-Ying, Chun, Steven T., Inzalaco, Jake, Turjman, Sue, Ghiam, Sean, Jeong-Kim, Jiho, Tolstoff, Sasha, Yampolsky, Sabina V., Sawant, Onkar B., Rabinowitz, Yaron S., Maguen, Ezra, Hamrah, Pedram, Svendsen, Clive N., Saghizadeh, Mehrnoosh, Ljubimova, Julia Y., Kramerov, Andrei A., Ljubimov, Alexander V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10474199/
https://www.ncbi.nlm.nih.gov/pubmed/37460827
http://dx.doi.org/10.1007/s00125-023-05960-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10474199/
https://www.ncbi.nlm.nih.gov/pubmed/37460827
http://dx.doi.org/10.1007/s00125-023-05960-1

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