Histone H3 K27M-mediated regulation of cancer cell stemness and differentiation in diffuse midline glioma

Therapeutic resistance remains a major obstacle to preventing progression of H3K27M-altered Diffuse Midline Glioma (DMG). Resistance is driven in part by ALDH-positive cancer stem cells (CSC), with high ALDH1A3 expression observed in H3K27M-mutant DMG biopsies. We hypothesized that ALDH-mediated ste...

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Detalles Bibliográficos
Autores principales: Sharma, Monika, Barravecchia, Ivana, Magnuson, Brian, Ferris, Sarah F., Apfelbaum, April, Mbah, Nneka E., Cruz, Jeanette, Krishnamoorthy, Varunkumar, Teis, Robert, Kauss, McKenzie, Koschmann, Carl, Lyssiotis, Costas A., Ljungman, Mats, Galban, Stefanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10474232/
https://www.ncbi.nlm.nih.gov/pubmed/37647805
http://dx.doi.org/10.1016/j.neo.2023.100931

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10474232/
https://www.ncbi.nlm.nih.gov/pubmed/37647805
http://dx.doi.org/10.1016/j.neo.2023.100931

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