Cargando…

ALKBH5 facilitates CYP1B1 mRNA degradation via m6A demethylation to alleviate MSC senescence and osteoarthritis progression

Improving health and delaying aging is the focus of medical research. Previous studies have shown that mesenchymal stem cell (MSC) senescence is closely related to organic aging and the development of aging-related diseases such as osteoarthritis (OA). m6A is a common RNA modification that plays an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ye, Guiwen, Li, Jinteng, Yu, Wenhui, Xie, Zhongyu, Zheng, Guan, Liu, Wenjie, Wang, Shan, Cao, Qian, Lin, Jiajie, Su, Zepeng, Li, Dateng, Che, Yunshu, Fan, Shuai, Wang, Peng, Wu, Yanfeng, Shen, Huiyong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10474288/ https://www.ncbi.nlm.nih.gov/pubmed/37524872 http://dx.doi.org/10.1038/s12276-023-01059-0

Ejemplares similares

BMAL1-TTK-H2Bub1 loop deficiency contributes to impaired BM-MSC-mediated bone formation in senile osteoporosis
por: Jinteng, Li, et al.
Publicado: (2023)

Targeting macrophage M1 polarization suppression through PCAF inhibition alleviates autoimmune arthritis via synergistic NF-κB and H3K9Ac blockade
por: Li, Jinteng, et al.
Publicado: (2023)

Correction: Targeting macrophage M1 polarization suppression through PCAF inhibition alleviates autoimmune arthritis via synergistic NF-κB and H3K9Ac blockade
por: Li, Jinteng, et al.
Publicado: (2023)

TNF-α-mediated m(6)A modification of ELMO1 triggers directional migration of mesenchymal stem cell in ankylosing spondylitis
por: Xie, Zhongyu, et al.
Publicado: (2021)

Decrotonylation of AKT1 promotes AKT1 phosphorylation and activation during myogenic differentiation
por: Qian, Zhengyu, et al.
Publicado: (2022)

The m(6)A methyltransferase METTL16 negatively regulates MCP1 expression in mesenchymal stem cells during monocyte recruitment
por: Zhang, Zhaoqiang, et al.
Publicado: (2023)

Single-cell RNA sequencing analysis of human bone-marrow-derived mesenchymal stem cells and functional subpopulation identification
por: Xie, Zhongyu, et al.
Publicado: (2022)

The N(6)-methyladenosine demethylase ALKBH5 negatively regulates the osteogenic differentiation of mesenchymal stem cells through PRMT6
por: Li, Zhaofeng, et al.
Publicado: (2021)

LncRNA MRF drives the regulatory function on monocyte recruitment and polarization through HNRNPD-MCP1 axis in mesenchymal stem cells
por: Lin, Jiajie, et al.
Publicado: (2022)

Osteogenic differentiation of mesenchymal stem cells promotes c-Jun-dependent secretion of interleukin 8 and mediates the migration and differentiation of CD4(+) T cells
por: Ye, Feng, et al.
Publicado: (2022)

Iron deficiency–induced ferritinophagy impairs skeletal muscle regeneration through RNF20-mediated H2Bub1 modification
por: Che, Yunshu, et al.
Publicado: (2023)

Aberrantly Expressed lncRNAs and mRNAs of Osteogenically Differentiated Mesenchymal Stem Cells in Ossification of the Posterior Longitudinal Ligament
por: Cai, Zhaopeng, et al.
Publicado: (2020)

ALKBH3-dependent m(1)A demethylation of Aurora A mRNA inhibits ciliogenesis
por: Kuang, Wenjun, et al.
Publicado: (2022)

GAS5 protects against osteoporosis by targeting UPF1/SMAD7 axis in osteoblast differentiation
por: Li, Ming, et al.
Publicado: (2020)

ALKBH5 regulates cardiomyocyte proliferation and heart regeneration by demethylating the mRNA of YTHDF1
por: Han, Zhenbo, et al.
Publicado: (2021)

Variations in the Gut Microbiota in Breast Cancer Occurrence and Bone Metastasis
por: Wenhui, Yu, et al.
Publicado: (2022)

ALKBH5-mediated m(6)A demethylation of FOXM1 mRNA promotes progression of uveal melanoma
por: Hao, Lili, et al.
Publicado: (2021)

LncRNA‐mRNA expression profiles and functional networks in osteoclast differentiation
por: Liu, Wenjie, et al.
Publicado: (2020)

Super enhancers targeting ZBTB16 in osteogenesis protect against osteoporosis
por: Yu, Wenhui, et al.
Publicado: (2023)

Author Correction: Super enhancers targeting ZBTB16 in osteogenesis protect against osteoporosis
por: Yu, Wenhui, et al.
Publicado: (2023)

IRF2‐mediated upregulation of lncRNA HHAS1 facilitates the osteogenic differentiation of bone marrow‐derived mesenchymal stem cells by acting as a competing endogenous RNA
por: Ye, Guiwen, et al.
Publicado: (2021)

Meclofenamic acid selectively inhibits FTO demethylation of m(6)A over ALKBH5
por: Huang, Yue, et al.
Publicado: (2015)

Oxidative stress-mediated mitochondrial dysfunction facilitates mesenchymal stem cell senescence in ankylosing spondylitis
por: Ye, Guiwen, et al.
Publicado: (2020)

ALKBH1‐mediated m(1)A demethylation of METTL3 mRNA promotes the metastasis of colorectal cancer by downregulating SMAD7 expression
por: Chen, Wenwen, et al.
Publicado: (2022)

ALKBH5-mediated m(6)A demethylation of lncRNA PVT1 plays an oncogenic role in osteosarcoma
por: Chen, Shuo, et al.
Publicado: (2020)

K235 acetylation couples with PSPC1 to regulate the m(6)A demethylation activity of ALKBH5 and tumorigenesis
por: Zhang, Xiao-Lan, et al.
Publicado: (2023)

Long noncoding RNA repressor of adipogenesis negatively regulates the adipogenic differentiation of mesenchymal stem cells through the hnRNP A1‐PTX3‐ERK axis
por: Pan, Yiqian, et al.
Publicado: (2020)

ALKBH5-mediated m(6)A demethylation of HS3ST3B1-IT1 prevents osteoarthritis progression
por: Tang, Yuting, et al.
Publicado: (2023)

Targeted mRNA demethylation using an engineered dCas13b-ALKBH5 fusion protein
por: Li, Jiexin, et al.
Publicado: (2020)

Choreography of methylation: KDM4C histone demethylation enables ALKBH5 m6A RNA demethylation to sustain AML stem cells
por: Sarma, Pranjal, et al.
Publicado: (2020)

ALKBH5 Promotes Multiple Myeloma Tumorigenicity through inducing m(6)A-demethylation of SAV1 mRNA and Myeloma Stem Cell Phenotype
por: Yu, Tingting, et al.
Publicado: (2022)

lncRNA-mRNA expression profiles and functional networks of mesenchymal stromal cells involved in monocyte regulation
por: Li, Ming, et al.
Publicado: (2019)

Alpinetin alleviates osteoporosis by promoting osteogenic differentiation in BMSCs by triggering autophagy via PKA/mTOR/ULK1 signaling
por: Zeng, Chenying, et al.
Publicado: (2022)

ALKBH4-dependent demethylation of actin regulates actomyosin dynamics
por: Li, Ming-Ming, et al.
Publicado: (2013)

ALKBH5-mediated m(6)A demethylation fuels cutaneous wound re-epithelialization by enhancing PELI2 mRNA stability
por: Huang, Xin, et al.
Publicado: (2023)

Modifying the m(6)A brain methylome by ALKBH5-mediated demethylation: a new contender for synaptic tagging
por: Martinez De La Cruz, Braulio, et al.
Publicado: (2021)

Autophagy-Mediated Activation of Mucosal-Associated Invariant T Cells Driven by Mesenchymal Stem Cell-Derived IL-15
por: Ye, Guiwen, et al.
Publicado: (2021)

ALKBH5‐mediated m(6)A demethylation of TIRAP mRNA promotes radiation‐induced liver fibrosis and decreases radiosensitivity of hepatocellular carcinoma
por: Chen, Yuhan, et al.
Publicado: (2023)

ALKBH5 activates FAK signaling through m6A demethylation in ITGB1 mRNA and enhances tumor-associated lymphangiogenesis and lymph node metastasis in ovarian cancer
por: Sun, Rui, et al.
Publicado: (2023)

ALKBH5-HOXA10 loop-mediated JAK2 m6A demethylation and cisplatin resistance in epithelial ovarian cancer
por: Nie, Sipei, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_brld6sceq4dgve55tljij31ftn