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Combating pan-coronavirus infection by indomethacin through simultaneously inhibiting viral replication and inflammatory response
Severe infections with coronaviruses are often accompanied with hyperinflammation, requiring therapeutic strategies to simultaneously tackle the virus and inflammation. By screening a safe-in-human broad-spectrum antiviral agents library, we identified that indomethacin can inhibit pan-coronavirus i...
Autores principales: | Wang, Yining, Li, Pengfei, Xu, Lei, de Vries, Annemarie C., Rottier, Robbert J., Wang, Wenshi, Crombag, Marie-Rose B.S., Peppelenbosch, Maikel P., Kainov, Denis E., Pan, Qiuwei |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10474465/ https://www.ncbi.nlm.nih.gov/pubmed/37664584 http://dx.doi.org/10.1016/j.isci.2023.107631 |
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