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Effectiveness and safety of mesenchymal stem/stromal cell for radiation-induced hyposalivation and xerostomia in previous head and neck cancer patients (MESRIX-III): a study protocol for a single-centre, double-blinded, randomised, placebo-controlled, phase II study

BACKGROUND: A predominant side effect of radiotherapy for head and neck cancer is salivary gland hypofunction and xerostomia leading to debilitating oral disorders and impaired quality of life (QoL). Intraglandular mesenchymal stem cell therapy has shown promising results as a treatment for xerostom...

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Detalles Bibliográficos
Autores principales: Jakobsen, Kathrine Kronberg, Carlander, Amanda-Louise Fenger, Grønhøj, Christian, Todsen, Tobias, Melchiors, Jacob, Paaske, Natasja, Madsen, Anne Kathrine Østergaard, Kastrup, Jens, Ekblond, Annette, Haack-Sørensen, Mandana, Farhadi, Mohammad, Maare, Christian, Friborg, Jeppe, Lynggard, Charlotte Duch, von Buchwald, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10474624/
https://www.ncbi.nlm.nih.gov/pubmed/37658468
http://dx.doi.org/10.1186/s13063-023-07594-5