Nephroprotective effects of Datura stramonium leaves against methotrexate nephrotoxicity via attenuation of oxidative stress-mediated inflammation and apoptosis in rats

OBJECTIVE: Methotrexate (MTX) is a frontline antimetabolite anticancer drug which is used in different cancer treatments but its nephrotoxicity is a notable drawback that limits its clinical use. The present study was undertaken to examine whether Datura stramonium leaf extract (DSLE) could block MT...

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Detalles Bibliográficos
Autores principales: Alum, Esther U, Famurewa, Ademola C., Orji, Obasi U, Aja, Patrick M, Nwite, Felix, Ohuche, Simon E, Ukasoanya, Stanley C, Nnaji, Lucy O, Joshua, Deborah, Igwe, Kingsley U, Chima, Stephen F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mashhad University of Medical Sciences 2023
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10474919/
https://www.ncbi.nlm.nih.gov/pubmed/37663387
http://dx.doi.org/10.22038/AJP.2023.21903

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10474919/
https://www.ncbi.nlm.nih.gov/pubmed/37663387
http://dx.doi.org/10.22038/AJP.2023.21903

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