TAZ2 truncation confers overactivation of p300 and cellular vulnerability to HDAC inhibition

The histone acetyltransferase p300/CBP is composed of several conserved domains, among which, the TAZ2 domain is known as a protein-protein interaction domain that binds to E1A and various transcription factors. Here we show that TAZ2 has a HAT autoinhibitory function. Truncating p300/CBP at TAZ2 le...

Descripción completa

Detalles Bibliográficos
Autores principales: Xu, Longxia, Xuan, Hongwen, He, Wei, Zhang, Liang, Huang, Mengying, Li, Kuai, Wen, Hong, Xu, Han, Shi, Xiaobing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475075/
https://www.ncbi.nlm.nih.gov/pubmed/37660055
http://dx.doi.org/10.1038/s41467-023-41245-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475075/
https://www.ncbi.nlm.nih.gov/pubmed/37660055
http://dx.doi.org/10.1038/s41467-023-41245-2

Ejemplares similares