Epigenetic inheritance is unfaithful at intermediately methylated CpG sites

DNA methylation at the CpG dinucleotide is considered a stable epigenetic mark due to its presumed long-term inheritance through clonal expansion. Here, we perform high-throughput bisulfite sequencing on clonally derived somatic cell lines to quantitatively measure methylation inheritance at the nuc...

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Detalles Bibliográficos
Autores principales: Hay, Amir D., Kessler, Noah J., Gebert, Daniel, Takahashi, Nozomi, Tavares, Hugo, Teixeira, Felipe K., Ferguson-Smith, Anne C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475082/
https://www.ncbi.nlm.nih.gov/pubmed/37660134
http://dx.doi.org/10.1038/s41467-023-40845-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475082/
https://www.ncbi.nlm.nih.gov/pubmed/37660134
http://dx.doi.org/10.1038/s41467-023-40845-2

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