Selective steroidogenic cytochrome P450 haem iron ligation by steroid-derived isonitriles

Alkyl isonitriles, R—NC, have previously been shown to ligate the heme (haem) iron of cytochromes P450 in both accessible oxidation states (ferrous, Fe(2+), and ferric, Fe(3+)). Herein, the preparation of four steroid-derived isonitriles and their interactions with several P450s, including the stero...

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Detalles Bibliográficos
Autores principales: Richard, Alaina M., Wong, Nathan R., Harris, Kurt, Sundar, Reethy, Scott, Emily E., Pochapsky, Thomas C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475101/
https://www.ncbi.nlm.nih.gov/pubmed/37660137
http://dx.doi.org/10.1038/s42004-023-00994-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475101/
https://www.ncbi.nlm.nih.gov/pubmed/37660137
http://dx.doi.org/10.1038/s42004-023-00994-3

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