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Selective steroidogenic cytochrome P450 haem iron ligation by steroid-derived isonitriles
Alkyl isonitriles, R—NC, have previously been shown to ligate the heme (haem) iron of cytochromes P450 in both accessible oxidation states (ferrous, Fe(2+), and ferric, Fe(3+)). Herein, the preparation of four steroid-derived isonitriles and their interactions with several P450s, including the stero...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475101/ https://www.ncbi.nlm.nih.gov/pubmed/37660137 http://dx.doi.org/10.1038/s42004-023-00994-3 |