Rescue of dendritic cells from glycolysis inhibition improves cancer immunotherapy in mice

Inhibition of glycolysis in immune cells and cancer cells diminishes their activity, and thus combining immunotherapies with glycolytic inhibitors is challenging. Herein, a strategy is presented where glycolysis is inhibited in cancer cells using PFK15 (inhibitor of PFKFB3, rate-limiting step in gly...

Descripción completa

Detalles Bibliográficos
Autores principales: Inamdar, Sahil, Suresh, Abhirami P., Mangal, Joslyn L., Ng, Nathan D., Sundem, Alison, Wu, Christopher, Lintecum, Kelly, Thumsi, Abhirami, Khodaei, Taravat, Halim, Michelle, Appel, Nicole, Jaggarapu, Madhan Mohan Chandra Sekhar, Esrafili, Arezoo, Yaron, Jordan R., Curtis, Marion, Acharya, Abhinav P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475105/
https://www.ncbi.nlm.nih.gov/pubmed/37660049
http://dx.doi.org/10.1038/s41467-023-41016-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475105/
https://www.ncbi.nlm.nih.gov/pubmed/37660049
http://dx.doi.org/10.1038/s41467-023-41016-z

Ejemplares similares