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FAM3A reshapes VSMC fate specification in abdominal aortic aneurysm by regulating KLF4 ubiquitination

Reprogramming of vascular smooth muscle cell (VSMC) differentiation plays an essential role in abdominal aortic aneurysm (AAA). However, the underlying mechanisms are still unclear. We explore the expression of FAM3A, a newly identified metabolic cytokine, and whether and how FAM3A regulates VSMC di...

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Detalles Bibliográficos
Autores principales: Lei, Chuxiang, Kan, Haoxuan, Xian, Xiangyu, Chen, Wenlin, Xiang, Wenxuan, Song, Xiaohong, Wu, Jianqiang, Yang, Dan, Zheng, Yuehong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475135/
https://www.ncbi.nlm.nih.gov/pubmed/37660071
http://dx.doi.org/10.1038/s41467-023-41177-x