Cargando…
TNFα induced by DNA-sensing in macrophage compromises retinal pigment epithelial (RPE) barrier function
Increasing evidence suggests that chronic inflammation plays an important role in the pathogenesis of age-related macular degeneration (AMD); however, the precise pathogenic stressors and sensors, and their impact on disease progression remain unclear. Several studies have demonstrated that type I i...
Autores principales: | Twarog, Michael, Schustak, Joshua, Xu, YongYao, Coble, Matthew, Dolan, Katie, Esterberg, Robert, Huang, Qian, Saint-Geniez, Magali, Bao, Yi |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475136/ https://www.ncbi.nlm.nih.gov/pubmed/37660150 http://dx.doi.org/10.1038/s41598-023-41610-7 |
Ejemplares similares
-
Mechanism of Nucleic Acid Sensing in Retinal Pigment Epithelium (RPE): RIG-I Mediates Type I Interferon Response in Human RPE
por: Schustak, Joshua, et al.
Publicado: (2021) -
Zinc transport from the endoplasmic reticulum to the cytoplasm via Zip7 is necessary for barrier dysfunction mediated by inflammatory signaling in RPE cells
por: Xu, YongYao, et al.
Publicado: (2022) -
Loss of PGC-1α in RPE induces mesenchymal transition and promotes retinal degeneration
por: Rosales, Mariana Aparecida Brunini, et al.
Publicado: (2019) -
Correction: Loss of PGC-1α in RPE induces mesenchymal transition and promotes retinal degeneration
por: Rosales, Mariana Aparecida Brunini, et al.
Publicado: (2019) -
Identification of a synergistic interaction between endothelial cells and retinal pigment epithelium
por: Spencer, Carrie, et al.
Publicado: (2017)