Efficacy and safety of fecal microbiota transplantation in the treatment of ulcerative colitis: a systematic review and meta-analysis
To explore the efficacy and safety of fecal microbiota transplantation (FMT) as a treatment approach for ulcerative colitis (UC), a comprehensive systematic review and meta-analysis of randomized controlled trials was conducted. To collect and evaluate randomized controlled trials of high quality on...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475461/ https://www.ncbi.nlm.nih.gov/pubmed/37661203 http://dx.doi.org/10.1038/s41598-023-41182-6 |
_version_ | 1785100723710590976 |
---|---|
author | Feng, Jing Chen, Yexin Liu, Yan Lin, Lin Lin, Xiujuan Gong, Wenxiu Xia, Rongmu He, Jianquan Sheng, Jianwen Cai, Huimei Xiao, Chuanxing |
author_facet | Feng, Jing Chen, Yexin Liu, Yan Lin, Lin Lin, Xiujuan Gong, Wenxiu Xia, Rongmu He, Jianquan Sheng, Jianwen Cai, Huimei Xiao, Chuanxing |
author_sort | Feng, Jing |
collection | PubMed |
description | To explore the efficacy and safety of fecal microbiota transplantation (FMT) as a treatment approach for ulcerative colitis (UC), a comprehensive systematic review and meta-analysis of randomized controlled trials was conducted. To collect and evaluate randomized controlled trials of high quality on FMT for UC, we searched a number of databases, including PubMed, Web of Science, Cochrane, Embase, and Medline, for studies published between the establishment of the databases and March 2023. We conducted a meta-analysis of the studies using Review Manager software (version 5.4.1) to determine the differences in rates of remission and adverse reactions between the FMT group and the control group, utilizing the risk ratio (RR) and 95% confidence interval (CI) to combine our findings. A total of 13 randomized controlled trials (RCTs) on the efficacy of FMT in patients with UC were included in the study, in which 580 patients participated, including 293 patients treated with FMT and 287 control subjects. Meta-analysis revealed that clinical remission was significantly better in the FMT group than in the control group [RR = 1.73; 95% CI = (1.41, 2.12); P < 0.00001]; endoscopic remission was significantly better in the FMT group than in the control group [RR = 1.74; 95% CI = (1.24, 2.44); P = 0.001]. Additionally, there were no significant differences in the incidence of adverse reactions between the two groups [RR = 1.00; 95% CI = (0.86, 1.15); P = 0.96]. Fecal microbiota transplantation has shown potential as a therapeutic intervention for inducing clinical remission in ulcerative colitis UC; nevertheless, the attainment of endoscopic remission and the maintenance of long-term remission continue to present challenges. Safety concerns persist throughout the treatment process, necessitating the implementation of measures to augment both safety and success rates. |
format | Online Article Text |
id | pubmed-10475461 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-104754612023-09-05 Efficacy and safety of fecal microbiota transplantation in the treatment of ulcerative colitis: a systematic review and meta-analysis Feng, Jing Chen, Yexin Liu, Yan Lin, Lin Lin, Xiujuan Gong, Wenxiu Xia, Rongmu He, Jianquan Sheng, Jianwen Cai, Huimei Xiao, Chuanxing Sci Rep Article To explore the efficacy and safety of fecal microbiota transplantation (FMT) as a treatment approach for ulcerative colitis (UC), a comprehensive systematic review and meta-analysis of randomized controlled trials was conducted. To collect and evaluate randomized controlled trials of high quality on FMT for UC, we searched a number of databases, including PubMed, Web of Science, Cochrane, Embase, and Medline, for studies published between the establishment of the databases and March 2023. We conducted a meta-analysis of the studies using Review Manager software (version 5.4.1) to determine the differences in rates of remission and adverse reactions between the FMT group and the control group, utilizing the risk ratio (RR) and 95% confidence interval (CI) to combine our findings. A total of 13 randomized controlled trials (RCTs) on the efficacy of FMT in patients with UC were included in the study, in which 580 patients participated, including 293 patients treated with FMT and 287 control subjects. Meta-analysis revealed that clinical remission was significantly better in the FMT group than in the control group [RR = 1.73; 95% CI = (1.41, 2.12); P < 0.00001]; endoscopic remission was significantly better in the FMT group than in the control group [RR = 1.74; 95% CI = (1.24, 2.44); P = 0.001]. Additionally, there were no significant differences in the incidence of adverse reactions between the two groups [RR = 1.00; 95% CI = (0.86, 1.15); P = 0.96]. Fecal microbiota transplantation has shown potential as a therapeutic intervention for inducing clinical remission in ulcerative colitis UC; nevertheless, the attainment of endoscopic remission and the maintenance of long-term remission continue to present challenges. Safety concerns persist throughout the treatment process, necessitating the implementation of measures to augment both safety and success rates. Nature Publishing Group UK 2023-09-03 /pmc/articles/PMC10475461/ /pubmed/37661203 http://dx.doi.org/10.1038/s41598-023-41182-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Feng, Jing Chen, Yexin Liu, Yan Lin, Lin Lin, Xiujuan Gong, Wenxiu Xia, Rongmu He, Jianquan Sheng, Jianwen Cai, Huimei Xiao, Chuanxing Efficacy and safety of fecal microbiota transplantation in the treatment of ulcerative colitis: a systematic review and meta-analysis |
title | Efficacy and safety of fecal microbiota transplantation in the treatment of ulcerative colitis: a systematic review and meta-analysis |
title_full | Efficacy and safety of fecal microbiota transplantation in the treatment of ulcerative colitis: a systematic review and meta-analysis |
title_fullStr | Efficacy and safety of fecal microbiota transplantation in the treatment of ulcerative colitis: a systematic review and meta-analysis |
title_full_unstemmed | Efficacy and safety of fecal microbiota transplantation in the treatment of ulcerative colitis: a systematic review and meta-analysis |
title_short | Efficacy and safety of fecal microbiota transplantation in the treatment of ulcerative colitis: a systematic review and meta-analysis |
title_sort | efficacy and safety of fecal microbiota transplantation in the treatment of ulcerative colitis: a systematic review and meta-analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475461/ https://www.ncbi.nlm.nih.gov/pubmed/37661203 http://dx.doi.org/10.1038/s41598-023-41182-6 |
work_keys_str_mv | AT fengjing efficacyandsafetyoffecalmicrobiotatransplantationinthetreatmentofulcerativecolitisasystematicreviewandmetaanalysis AT chenyexin efficacyandsafetyoffecalmicrobiotatransplantationinthetreatmentofulcerativecolitisasystematicreviewandmetaanalysis AT liuyan efficacyandsafetyoffecalmicrobiotatransplantationinthetreatmentofulcerativecolitisasystematicreviewandmetaanalysis AT linlin efficacyandsafetyoffecalmicrobiotatransplantationinthetreatmentofulcerativecolitisasystematicreviewandmetaanalysis AT linxiujuan efficacyandsafetyoffecalmicrobiotatransplantationinthetreatmentofulcerativecolitisasystematicreviewandmetaanalysis AT gongwenxiu efficacyandsafetyoffecalmicrobiotatransplantationinthetreatmentofulcerativecolitisasystematicreviewandmetaanalysis AT xiarongmu efficacyandsafetyoffecalmicrobiotatransplantationinthetreatmentofulcerativecolitisasystematicreviewandmetaanalysis AT hejianquan efficacyandsafetyoffecalmicrobiotatransplantationinthetreatmentofulcerativecolitisasystematicreviewandmetaanalysis AT shengjianwen efficacyandsafetyoffecalmicrobiotatransplantationinthetreatmentofulcerativecolitisasystematicreviewandmetaanalysis AT caihuimei efficacyandsafetyoffecalmicrobiotatransplantationinthetreatmentofulcerativecolitisasystematicreviewandmetaanalysis AT xiaochuanxing efficacyandsafetyoffecalmicrobiotatransplantationinthetreatmentofulcerativecolitisasystematicreviewandmetaanalysis |