Generation of inactivated IL2RG and RAG1 monkeys with severe combined immunodeficiency using base editing

Severe combined immunodeficiency (SCID) encompasses a range of inherited disorders that lead to a profound deterioration of the immune system. Among the pivotal genes associated with SCID, RAG1 and IL2RG play crucial roles. IL2RG is essential for the development, differentiation, and functioning of...

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Detalles Bibliográficos
Autores principales: Zheng, Xiao, Huang, Chunhui, Lin, Yingqi, Han, Bofeng, Chen, Yizhi, Li, Caijuan, Li, Jiawei, Ding, Yongyan, Song, Xichen, Wang, Wei, Liang, Weien, Wu, Jianhao, Wu, Jiaxi, Gao, Jiale, Wei, Chengxi, Zhang, Xudong, Tu, Zhuchi, Yan, Sen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475462/
https://www.ncbi.nlm.nih.gov/pubmed/37661226
http://dx.doi.org/10.1038/s41392-023-01544-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475462/
https://www.ncbi.nlm.nih.gov/pubmed/37661226
http://dx.doi.org/10.1038/s41392-023-01544-y

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