Cargando…

Generation of inactivated IL2RG and RAG1 monkeys with severe combined immunodeficiency using base editing

Severe combined immunodeficiency (SCID) encompasses a range of inherited disorders that lead to a profound deterioration of the immune system. Among the pivotal genes associated with SCID, RAG1 and IL2RG play crucial roles. IL2RG is essential for the development, differentiation, and functioning of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zheng, Xiao, Huang, Chunhui, Lin, Yingqi, Han, Bofeng, Chen, Yizhi, Li, Caijuan, Li, Jiawei, Ding, Yongyan, Song, Xichen, Wang, Wei, Liang, Weien, Wu, Jianhao, Wu, Jiaxi, Gao, Jiale, Wei, Chengxi, Zhang, Xudong, Tu, Zhuchi, Yan, Sen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475462/ https://www.ncbi.nlm.nih.gov/pubmed/37661226 http://dx.doi.org/10.1038/s41392-023-01544-y

Ejemplares similares

Tauopathy promotes spinal cord-dependent production of toxic amyloid-beta in transgenic monkeys
por: Tu, Zhuchi, et al.
Publicado: (2023)

Intravenous AAV9 administration results in safe and widespread distribution of transgene in the brain of mini-pig
por: Lin, Yingqi, et al.
Publicado: (2023)

A Specific Mini‐Intrabody Mediates Lysosome Degradation of Mutant Huntingtin (Adv. Sci. 31/2023)
por: Li, Caijuan, et al.
Publicado: (2023)

A Specific Mini‐Intrabody Mediates Lysosome Degradation of Mutant Huntingtin
por: Li, Caijuan, et al.
Publicado: (2023)

Increased and prolonged human norovirus infection in RAG2/IL2RG deficient gnotobiotic pigs with severe combined immunodeficiency
por: Lei, Shaohua, et al.
Publicado: (2016)

Biological Characteristics of Severe Combined Immunodeficient Mice Produced by CRISPR/Cas9-Mediated Rag2 and IL2rg Mutation
por: Zhao, Yong, et al.
Publicado: (2019)

Allogeneic and xenogeneic lymphoid reconstitution in a RAG2(−/−)IL2RG(y/−) severe combined immunodeficient pig: A preclinical model for intrauterine hematopoietic transplantation
por: Sper, Renan B., et al.
Publicado: (2022)

Application of CRISPR/Cas9 System in Establishing Large Animal Models
por: Lin, Yingqi, et al.
Publicado: (2022)

Gut Microbiota Contributes to Resistance Against Pneumococcal Pneumonia in Immunodeficient Rag(−/−) Mice
por: Felix, Krysta M., et al.
Publicado: (2018)

Transfer of PBMC From SSc Patients Induces Autoantibodies and Systemic Inflammation in Rag2-/-/IL2rg-/- Mice
por: Yue, Xiaoyang, et al.
Publicado: (2021)

Severe combined immunodeficiency syndrome with RAG1 mutation gene - case report
por: Lima, Ana Lúcia, et al.
Publicado: (2015)

Impaired sense of smell and altered olfactory system in RAG-1(−∕−) immunodeficient mice
por: Rattazzi, Lorenza, et al.
Publicado: (2015)

Survival‐Assured Liver Injury Preconditioning (SALIC) Enables Robust Expansion of Human Hepatocytes in Fah (–/–) Rag2 (–/–) IL2rg (–/–) Rats
por: Zhang, Ludi, et al.
Publicado: (2021)

Sequence of the RAG1 and RAG2 Intergenic Region in Zebrafish (Danio rerio)
por: Bertrand III, F. E., et al.
Publicado: (1998)

Expansion of immunoglobulin-secreting cells and defects in B cell tolerance in Rag-dependent immunodeficiency
por: Walter, Jolan E., et al.
Publicado: (2010)

The R229Q mutation of Rag2 does not characterize severe immunodeficiency in mice
por: Jin, Young, et al.
Publicado: (2019)

Predicting the Occurrence of Variants in RAG1 and RAG2
por: Lawless, Dylan, et al.
Publicado: (2019)

The SRG rat, a Sprague-Dawley Rag2/Il2rg double-knockout validated for human tumor oncology studies
por: Noto, Fallon K., et al.
Publicado: (2020)

DNA melting initiates the RAG catalytic pathway
por: Ru, Heng, et al.
Publicado: (2018)

The Rag Weed
Publicado: (1886)

A variant of RAG1 gene identified in severe combined immunodeficiency: a case report
por: Zhang, Xinping, et al.
Publicado: (2023)

Multiorgan Metastasis of Human HER-2(+) Breast Cancer in Rag2(−/−);Il2rg(−/−) Mice and Treatment with PI3K Inhibitor
por: Nanni, Patrizia, et al.
Publicado: (2012)

Classic piano rags : complete original for 81 rags
Publicado: (1973)

RAG1 targeting in the genome is dominated by chromatin interactions mediated by the non-core regions of RAG1 and RAG2
por: Maman, Yaakov, et al.
Publicado: (2016)

Biallelic modification of IL2RG leads to severe combined immunodeficiency in pigs
por: Kang, Jung-Taek, et al.
Publicado: (2016)

NOD-scidIl2rg(tm1Wjl) and NOD-Rag1(null)Il2rg(tm1Wjl): A Model for Stromal Cell–Tumor Cell Interaction for Human Colon Cancer
por: Maykel, Justin, et al.
Publicado: (2014)

Rag1 immunodeficiency‐induced early aging and senescence in zebrafish are dependent on chronic inflammation and oxidative stress
por: Novoa, Beatriz, et al.
Publicado: (2019)

Complete piano rags
por: Joplin, Scott, 1868-1917
Publicado: (1988)

Ragging: Let's say NO to it
por: Desai, Chetna
Publicado: (2009)

Working among Rags
por: Murray, J. Jardine
Publicado: (1859)

Sugar from Rags
Publicado: (1881)

CRISPR/Cas9-Mediated Deletion of Foxn1 in NOD/SCID/IL2rg(−/−) Mice Results in Severe Immunodeficiency
por: Wei, Xinru, et al.
Publicado: (2017)

A Novel Quantitative Fluorescent Reporter Assay for RAG Targets and RAG Activity
por: Trancoso, Inês, et al.
Publicado: (2013)

iPSC-Based Modeling of RAG2 Severe Combined Immunodeficiency Reveals Multiple T Cell Developmental Arrests
por: Themeli, Maria, et al.
Publicado: (2020)

Transplantation of Human Glial Progenitors to Immunodeficient Neonatal Mice with Amyotrophic Lateral Sclerosis (SOD1/rag2)
por: Stanaszek, Luiza, et al.
Publicado: (2022)

Partial correction of immunodeficiency by lentiviral vector gene therapy in mouse models carrying Rag1 hypomorphic mutations
por: Castiello, Maria Carmina, et al.
Publicado: (2023)

RAGs and BUGS: An alliance for autoimmunity
por: Rigoni, Rosita, et al.
Publicado: (2016)

Combined Immunodeficiency With Late-Onset Progressive Hypogammaglobulinemia and Normal B Cell Count in a Patient With RAG2 Deficiency
por: Dorna, Mayra B., et al.
Publicado: (2019)

Evolution of the RAG1-RAG2 locus: both proteins came from the same transposon
por: Kapitonov, Vladimir V, et al.
Publicado: (2015)

Clinical, Immunological, and Molecular Variability of RAG Deficiency: A Retrospective Analysis of 22 RAG Patients
por: Cifaldi, Cristina, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_itmp7tpfn1lahd5nq7sq4t4la1