Exploring the natural products chemical space through a molecular search to discover potential inhibitors that target the hypoxia-inducible factor (HIF) prolyl hydroxylase domain (PHD)

Introduction: Hypoxia-inducible factor (HIF) prolyl hydroxylase domain (PHD) enzymes are major therapeutic targets of anemia and ischemic/hypoxia diseases. To overcome safety issues, liver failure, and problems associated with on-/off-targets, natural products due to their novel and unique structure...

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Detalles Bibliográficos
Autores principales: Sayaf, Abrar Mohammad, Ullah Khalid, Saif, Hameed, Jawad Ahmed, Alshammari, Abdulrahman, Khan, Abbas, Mohammad, Anwar, Alghamdi, Saeed, Wei, Dong-Qing, Yeoh, KarKheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475833/
https://www.ncbi.nlm.nih.gov/pubmed/37670941
http://dx.doi.org/10.3389/fphar.2023.1202128

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475833/
https://www.ncbi.nlm.nih.gov/pubmed/37670941
http://dx.doi.org/10.3389/fphar.2023.1202128

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