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Single-cell multi-omics topic embedding reveals cell-type-specific and COVID-19 severity-related immune signatures

The advent of single-cell multi-omics sequencing technology makes it possible for researchers to leverage multiple modalities for individual cells and explore cell heterogeneity. However, the high-dimensional, discrete, and sparse nature of the data make the downstream analysis particularly challeng...

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Detalles Bibliográficos
Autores principales: Zhou, Manqi, Zhang, Hao, Bai, Zilong, Mann-Krzisnik, Dylan, Wang, Fei, Li, Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475851/
https://www.ncbi.nlm.nih.gov/pubmed/37671028
http://dx.doi.org/10.1016/j.crmeth.2023.100563