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Obesity and thinness: insights from genetics
Genetic disruption of key molecular components of the hypothalamic leptin–melanocortin pathway causes severe obesity in mice and humans. Physiological studies in people who carry these mutations have shown that the adipose tissue-derived hormone leptin primarily acts to defend against starvation. A...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The Royal Society
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475868/ https://www.ncbi.nlm.nih.gov/pubmed/37661743 http://dx.doi.org/10.1098/rstb.2022.0205 |