Orthogonal Inverse-Electron-Demand Cycloaddition Reactions Controlled by Frontier Molecular Orbital Interactions

[Image: see text] Chemoselective pairs of bioorthogonal reactants enable the simultaneous labeling of several biomolecules. Here, we access orthogonal click reactions by exploiting differences in frontier molecular orbital interaction energies in transition states. We establish that five-membered cy...

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Detalles Bibliográficos
Autores principales: Svatunek, Dennis, Chojnacki, Konrad, Deb, Titas, Eckvahl, Hannah, Houk, K. N., Franzini, Raphael M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476241/
https://www.ncbi.nlm.nih.gov/pubmed/37591496
http://dx.doi.org/10.1021/acs.orglett.3c02265

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476241/
https://www.ncbi.nlm.nih.gov/pubmed/37591496
http://dx.doi.org/10.1021/acs.orglett.3c02265

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