Gene-based burden scores identify rare variant associations for 28 blood biomarkers

BACKGROUND: A relevant part of the genetic architecture of complex traits is still unknown; despite the discovery of many disease-associated common variants. Polygenic risk score (PRS) models are based on the evaluation of the additive effects attributable to common variants and have been successful...

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Detalles Bibliográficos
Autores principales: Aldisi, Rana, Hassanin, Emadeldin, Sivalingam, Sugirthan, Buness, Andreas, Klinkhammer, Hannah, Mayr, Andreas, Fröhlich, Holger, Krawitz, Peter, Maj, Carlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476296/
https://www.ncbi.nlm.nih.gov/pubmed/37667186
http://dx.doi.org/10.1186/s12863-023-01155-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476296/
https://www.ncbi.nlm.nih.gov/pubmed/37667186
http://dx.doi.org/10.1186/s12863-023-01155-0

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