Upregulation of Epac1 Promotes Pericyte Loss by Inducing Mitochondrial Fission, Reactive Oxygen Species Production, and Apoptosis

PURPOSE: The pathogenic mechanisms behind the development of ischemic retinopathy are complex and poorly understood. This study investigates the involvement of exchange protein directly activated by cAMP (Epac)1 signaling in pericyte injury during ischemic retinopathy, including diabetic retinopathy...

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Detalles Bibliográficos
Autores principales: Yang, Wenli, Xia, Fan, Mei, Fang, Shi, Shuizhen, Robichaux, William G., Lin, Wei, Zhang, Wenbo, Liu, Hua, Cheng, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2023
Materias:
Retinal Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476449/
https://www.ncbi.nlm.nih.gov/pubmed/37651112
http://dx.doi.org/10.1167/iovs.64.11.34

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476449/
https://www.ncbi.nlm.nih.gov/pubmed/37651112
http://dx.doi.org/10.1167/iovs.64.11.34

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