Synthetic GM1 improves motor and memory dysfunctions in mice with monoallelic or biallelic disruption of GM3 synthase

This study attempts to answer the question of whether mice with biallelic and monoallelic disruption of the St3gal5 (GM3 synthase) gene might benefit from GM1 replacement therapy. The GM3 produced by this sialyltransferase gives rise to downstream GD3 and the ganglio‐series of gangliosides. The latt...

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Detalles Bibliográficos
Autores principales: Chowdhury, Suman, Kumar, Ranjeet, Zepeda, Evelyn, DeFrees, Shawn, Ledeen, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476560/
https://www.ncbi.nlm.nih.gov/pubmed/37401916
http://dx.doi.org/10.1002/2211-5463.13669

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476560/
https://www.ncbi.nlm.nih.gov/pubmed/37401916
http://dx.doi.org/10.1002/2211-5463.13669

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