A twin UGUA motif directs the balance between gene isoforms through CFIm and the mTORC1 signaling pathway

Alternative polyadenylation (APA) generates mRNA isoforms and diversifies gene expression. Here we report the discovery that the mTORC1 signaling pathway balances the expression of two Trim9/TRIM9 isoforms through APA regulation in human and mouse. We showed that CFIm components, CPSF6 and NUDT21, p...

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Detalles Bibliográficos
Autores principales: Herron, R Samuel, Kunisky, Alexander K, Madden, Jessica R, Anyaeche, Vivian I, Maung, May Z, Hwang, Hun-Way
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476966/
https://www.ncbi.nlm.nih.gov/pubmed/37665675
http://dx.doi.org/10.7554/eLife.85036

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476966/
https://www.ncbi.nlm.nih.gov/pubmed/37665675
http://dx.doi.org/10.7554/eLife.85036

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