APP-BACE1 Interaction and Intracellular Localization Regulate Aβ Production in iPSC-Derived Cortical Neurons

Alzheimer’s disease (AD) is characterized pathologically by amyloid β (Aβ)-containing plaques. Generation of Aβ from amyloid precursor protein (APP) by two enzymes, β- and γ-secretase, has therefore been in the AD research spotlight for decades. Despite this, how the physical interaction of APP with...

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Detalles Bibliográficos
Autores principales: Roselli, Sandra, Satir, Tugce Munise, Camacho, Rafael, Fruhwürth, Stefanie, Bergström, Petra, Zetterberg, Henrik, Agholme, Lotta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477112/
https://www.ncbi.nlm.nih.gov/pubmed/37355492
http://dx.doi.org/10.1007/s10571-023-01374-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477112/
https://www.ncbi.nlm.nih.gov/pubmed/37355492
http://dx.doi.org/10.1007/s10571-023-01374-0

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