An artesunate pharmacometric model to explain therapeutic responses in falciparum malaria

BACKGROUND: The artemisinins are potent and widely used antimalarial drugs that are eliminated rapidly. A simple concentration–effect pharmacometric model does not explain why dosing more frequently than once daily fails to augment parasite clearance and improve therapeutic responses in vivo. Artemi...

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Detalles Bibliográficos
Autores principales: Saralamba, Sompob, Simpson, Julie A, Choosri, Noppon, White, Lisa, Pan-Ngum, Wirichada, Dondorp, Arjen M, White, Nicholas J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477127/
https://www.ncbi.nlm.nih.gov/pubmed/37473441
http://dx.doi.org/10.1093/jac/dkad219

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477127/
https://www.ncbi.nlm.nih.gov/pubmed/37473441
http://dx.doi.org/10.1093/jac/dkad219

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