Reducing kidney uptake of radiolabelled exendin-4 using variants of the renally cleavable linker MVK

BACKGROUND: Peptidic radiotracers are preferentially excreted through the kidneys, which often results in high persistent renal retention of radioactivity, limiting or even preventing therapeutic clinical translation of these radiotracers. Exendin-4, which targets the glucagon-like-peptide 1 recepto...

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Detalles Bibliográficos
Autores principales: Trachsel, Belinda, Valpreda, Giulia, Lutz, Alexandra, Schibli, Roger, Mu, Linjing, Béhé, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477158/
https://www.ncbi.nlm.nih.gov/pubmed/37665477
http://dx.doi.org/10.1186/s41181-023-00206-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477158/
https://www.ncbi.nlm.nih.gov/pubmed/37665477
http://dx.doi.org/10.1186/s41181-023-00206-2

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