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Reducing kidney uptake of radiolabelled exendin-4 using variants of the renally cleavable linker MVK
BACKGROUND: Peptidic radiotracers are preferentially excreted through the kidneys, which often results in high persistent renal retention of radioactivity, limiting or even preventing therapeutic clinical translation of these radiotracers. Exendin-4, which targets the glucagon-like-peptide 1 recepto...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer International Publishing
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477158/ https://www.ncbi.nlm.nih.gov/pubmed/37665477 http://dx.doi.org/10.1186/s41181-023-00206-2 |