Expression of hypoxia-inducible genes is suppressed in altered gravity due to impaired nuclear HIF1α accumulation

Extravehicular activities, the backbone of manned space exploration programs, set astronauts into mild hypoxia. Unfortunately, microgravity aggravates threatening symptoms of hypoxia such as vision impairment and brain edema. Hypoxia-inducible factors (HIFs) sense cellular hypoxia and, subsequently,...

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Detalles Bibliográficos
Autores principales: Aboouf, Mostafa A., Thiel, Cora S., Borisov, Sergey M., Tauber, Svantje, Bönzli, Eva, Schetle, Nelli, Ullrich, Oliver, Gassmann, Max, Vogel, Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477221/
https://www.ncbi.nlm.nih.gov/pubmed/37666879
http://dx.doi.org/10.1038/s41598-023-41686-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477221/
https://www.ncbi.nlm.nih.gov/pubmed/37666879
http://dx.doi.org/10.1038/s41598-023-41686-1

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