Characterization of cooperative PS-oligo activation of human TLR9

Single-stranded phosphorothioate oligonucleotides (PS-oligos) can activate TLR9, leading to an innate immune response. This can occur with PS-oligos containing unmethylated CpG sites, the canonical motif, or PS-oligos that do not contain those motifs (non-CpG). Structural evidence shows that TLR9 co...

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Detalles Bibliográficos
Autores principales: Pollak, Adam J., Zhao, Luyi, Crooke, Stanley T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477407/
https://www.ncbi.nlm.nih.gov/pubmed/37675184
http://dx.doi.org/10.1016/j.omtn.2023.08.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477407/
https://www.ncbi.nlm.nih.gov/pubmed/37675184
http://dx.doi.org/10.1016/j.omtn.2023.08.011

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