Cargando…

Acyl-protein thioesterase1 alleviates senile osteoporosis by promoting osteoblast differentiation via depalmitoylation of BMPR1a

OBJECTIVE: Senile osteoporosis (SOP) is an aging-related disease. The depalmitoylating enzyme Acyl-protein thiesterase1 (APT1) is involved in disease regulation. This study explored the mechanism of APT1 in SOP. METHODS: Eight-week-old SAMP6 mice were selected as SOP models and SAMR1 mice were contr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ji, Changjiao, Dong, Qiaoyan, Liu, Huihui, Yang, Xiaodeng, Han, Yingguang, Zhu, Bingrui, Xing, Huaixin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Japanese Society for Regenerative Medicine 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477743/ https://www.ncbi.nlm.nih.gov/pubmed/37674692 http://dx.doi.org/10.1016/j.reth.2023.05.004

Ejemplares similares

Depalmitoylation by Palmitoyl-Protein Thioesterase 1 in Neuronal Health and Degeneration
por: Koster, Kevin P., et al.
Publicado: (2019)

Identification of substrates of palmitoyl protein thioesterase 1 highlights roles of depalmitoylation in disulfide bond formation and synaptic function
por: Gorenberg, Erica L., et al.
Publicado: (2022)

Trypanosoma brucei Acyl-Protein Thioesterase-like (TbAPT-L) Is a Lipase with Esterase Activity for Short and Medium-Chain Fatty Acids but Has No Depalmitoylation Activity
por: Brown, Robert W. B., et al.
Publicado: (2022)

Glucosamine delays the progression of osteoporosis in senile mice by promoting osteoblast autophagy
por: Su, Wei, et al.
Publicado: (2022)

Insights into the molecular basis of the palmitoylation and depalmitoylation of NCX1
por: Gök, Caglar, et al.
Publicado: (2021)

Protein S-acyltransferases and acyl protein thioesterases, regulation executors of protein S-acylation in plants
por: Li, Jincheng, et al.
Publicado: (2022)

Development of an activity-based probe for acyl-protein thioesterases
por: Garland, Megan, et al.
Publicado: (2018)

Targeting MC1R depalmitoylation to prevent melanomagenesis in redheads
por: Chen, Shuyang, et al.
Publicado: (2019)

Characterization of the acyl-ACP thioesterases from Koelreuteria paniculata reveals a new type of FatB thioesterase
por: Martins-Noguerol, R., et al.
Publicado: (2020)

Reversible Cysteine Acylation Regulates the Activity of Human Palmitoyl-Protein Thioesterase 1 (PPT1)
por: Segal-Salto, Michal, et al.
Publicado: (2016)

Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains
por: Abrami, Laurence, et al.
Publicado: (2021)

Two distinct domains contribute to the substrate acyl chain length selectivity of plant acyl-ACP thioesterase
por: Jing, Fuyuan, et al.
Publicado: (2018)

Daphnetin Alleviates Senile and Disuse Osteoporosis by Distinct Modulations of Bone Formation and Resorption
por: Gao, Jing, et al.
Publicado: (2022)

PPT1 regulation of HSP90α depalmitoylation participates in the pathogenesis of hyperandrogenism
por: Xue, Tongmin, et al.
Publicado: (2023)

Active and dynamic mitochondrial S-depalmitoylation revealed by targeted fluorescent probes
por: Kathayat, Rahul S., et al.
Publicado: (2018)

Senile osteoporosis - two models of physiotherapy
por: Walusiak, M, et al.
Publicado: (2009)

Acyl-Protein Thioesterase 2 Catalizes the Deacylation of Peripheral Membrane-Associated GAP-43
por: Tomatis, Vanesa M., et al.
Publicado: (2010)

2-Bromopalmitate Reduces Protein Deacylation by Inhibition of Acyl-Protein Thioesterase Enzymatic Activities
por: Pedro, Maria P., et al.
Publicado: (2013)

Evolutionary divergence and functions of the human acyl-CoA thioesterase gene (ACOT) family
por: Brocker, Chad, et al.
Publicado: (2010)

T181. PROTEIN ACYL-THIOESTERASE ENZYME ACTIVITY IN THE POSTMORTEM DORSOLATERAL PREFRONTAL CORTEX IN SCHIZOPHRENIA
por: Hopper, Shaun, et al.
Publicado: (2020)

Acyl-CoA thioesterase activity of peroxisomal ABC protein ABCD1 is required for the transport of very long-chain acyl-CoA into peroxisomes
por: Kawaguchi, Kosuke, et al.
Publicado: (2021)

Protective Effects of Acyl-coA Thioesterase 1 on Diabetic Heart via PPARα/PGC1α Signaling
por: Yang, Shenglan, et al.
Publicado: (2012)

Conformational Changes of Acyl Carrier Protein Switch the Chain Length Preference of Acyl-ACP Thioesterase ChFatB2
por: Yang, Tianxiang, et al.
Publicado: (2023)

Acyl-CoA thioesterase 1 prevents cardiomyocytes from Doxorubicin-induced ferroptosis via shaping the lipid composition
por: Liu, Yunchang, et al.
Publicado: (2020)

A fluorescent probe for cysteine depalmitoylation reveals dynamic APT signaling
por: Kathayat, Rahul S., et al.
Publicado: (2016)

Activity-dependent post-translational regulation of palmitoylating and depalmitoylating enzymes in the hippocampus
por: Abazari, Danya, et al.
Publicado: (2023)

Id4, a New Candidate Gene for Senile Osteoporosis, Acts as a Molecular Switch Promoting Osteoblast Differentiation
por: Tokuzawa, Yoshimi, et al.
Publicado: (2010)

Elevated BMPR2 expression amplifies osteoblast differentiation in ankylosing spondylitis
por: Jo, Sungsin, et al.
Publicado: (2023)

Distinct Acyl Protein Transferases and Thioesterases Control Surface Expression of Calcium-activated Potassium Channels
por: Tian, Lijun, et al.
Publicado: (2012)

Determinants of substrate specificity in a catalytically diverse family of acyl-ACP thioesterases from plants
por: Kalinger, Rebecca S., et al.
Publicado: (2023)

The Delay of Old Age and the Alleviation of Senility
por: Stockton, Charles G.
Publicado: (1905)

Wogonoside induces depalmitoylation and translocation of PLSCR1 and N‐RAS in primary acute myeloid leukaemia cells
por: Li, Hui, et al.
Publicado: (2018)

Palmitoyltransferase DHHC9 and acyl protein thioesterase APT1 modulate renal fibrosis through regulating β-catenin palmitoylation
por: Gu, Mengru, et al.
Publicado: (2023)

Depalmitoylated Ras traffics to and from the Golgi complex via a nonvesicular pathway
por: Goodwin, J. Shawn, et al.
Publicado: (2005)

Phylogenetic and experimental characterization of an acyl-ACP thioesterase family reveals significant diversity in enzymatic specificity and activity
por: Jing, Fuyuan, et al.
Publicado: (2011)

Acyl-CoA Thioesterase 8 and 11 as Novel Biomarkers for Clear Cell Renal Cell Carcinoma
por: Xu, Chao-Liang, et al.
Publicado: (2020)

Low expression of acyl-CoA thioesterase 13 is associated with poor prognosis in ovarian serous cystadenocarcinoma
por: Lv, Xiaofeng, et al.
Publicado: (2023)

Acyl-CoA Thioesterase 1 (ACOT1) Regulates PPARα to Couple Fatty Acid Flux With Oxidative Capacity During Fasting
por: Franklin, Mallory P., et al.
Publicado: (2017)

Relationship between senile osteoporosis and cardiovascular and cerebrovascular diseases
por: Hu, Xiaoying, et al.
Publicado: (2019)

Clinical effect of Zoledronic Acid in the treatment of Senile Osteoporosis
por: Kong, Li, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_j8psasudrmi046v7bosp423fmf