S-531011, a Novel Anti-Human CCR8 Antibody, Induces Potent Antitumor Responses through Depletion of Tumor-Infiltrating CCR8-Expressing Regulatory T Cells

Although regulatory T cells (Treg) are inhibitory immune cells that are essential for maintaining immune homeostasis, Tregs that infiltrate tumor tissue promote tumor growth by suppressing antitumor immunity. Selective reduction of tumor-infiltrating Tregs is, therefore, expected to activate antitum...

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Detalles Bibliográficos
Autores principales: Nagira, Yoji, Nagira, Morio, Nagai, Ryohei, Nogami, Wataru, Hirata, Michinari, Ueyama, Azumi, Yoshida, Tetsuya, Yoshikawa, Mai, Shinonome, Satomi, Yoshida, Hiroshi, Haruna, Miya, Miwa, Hiroto, Chatani, Natsumi, Ohkura, Naganari, Wada, Hisashi, Tanaka, Hidekazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Large Molecule Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477828/
https://www.ncbi.nlm.nih.gov/pubmed/37420296
http://dx.doi.org/10.1158/1535-7163.MCT-22-0570

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477828/
https://www.ncbi.nlm.nih.gov/pubmed/37420296
http://dx.doi.org/10.1158/1535-7163.MCT-22-0570

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