Location and Concentration of Aromatic‐Rich Segments Dictates the Percolating Inter‐Molecular Network and Viscoelastic Properties of Ageing Condensates

Maturation of functional liquid‐like biomolecular condensates into solid‐like aggregates has been linked to the onset of several neurodegenerative disorders. Low‐complexity aromatic‐rich kinked segments (LARKS) contained in numerous RNA‐binding proteins can promote aggregation by forming inter‐prote...

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Detalles Bibliográficos
Autores principales: Blazquez, Samuel, Sanchez‐Burgos, Ignacio, Ramirez, Jorge, Higginbotham, Tim, Conde, Maria M., Collepardo‐Guevara, Rosana, Tejedor, Andres R., Espinosa, Jorge R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477902/
https://www.ncbi.nlm.nih.gov/pubmed/37386790
http://dx.doi.org/10.1002/advs.202207742

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477902/
https://www.ncbi.nlm.nih.gov/pubmed/37386790
http://dx.doi.org/10.1002/advs.202207742

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