Position-Specific Enrichment Ratio Matrix scores predict antibody variant properties from deep sequencing data

MOTIVATION: Deep sequencing of antibody and related protein libraries after phage or yeast-surface display sorting is widely used to identify variants with increased affinity, specificity, and/or improvements in key biophysical properties. Conventional approaches for identifying optimal variants typ...

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Detalles Bibliográficos
Autores principales: Smith, Matthew D, Case, Marshall A, Makowski, Emily K, Tessier, Peter M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477941/
https://www.ncbi.nlm.nih.gov/pubmed/37478351
http://dx.doi.org/10.1093/bioinformatics/btad446

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477941/
https://www.ncbi.nlm.nih.gov/pubmed/37478351
http://dx.doi.org/10.1093/bioinformatics/btad446

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