Cargando…

Single-cell Profiling Uncovers a Muc4-Expressing Metaplastic Gastric Cell Type Sustained by Helicobacter pylori-driven Inflammation

Mechanisms for Helicobacter pylori (Hp)-driven stomach cancer are not fully understood. In a transgenic mouse model of gastric preneoplasia, concomitant Hp infection and induction of constitutively active KRAS (Hp+KRAS+) alters metaplasia phenotypes and elicits greater inflammation than either pertu...

Descripción completa

Detalles Bibliográficos
Autores principales:	O'Brien, Valerie P., Kang, Yuqi, Shenoy, Meera K., Finak, Greg, Young, William C., Dubrulle, Julien, Koch, Lisa, Rodriguez Martinez, Armando E., Williams, Jeffery, Donato, Elizabeth, Batra, Surinder K., Yeung, Cecilia C.S., Grady, William M., Koch, Meghan A., Gottardo, Raphael, Salama, Nina R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10478791/ https://www.ncbi.nlm.nih.gov/pubmed/37674528 http://dx.doi.org/10.1158/2767-9764.CRC-23-0142

Ejemplares similares

Role of MUC4-NIDO domain in the MUC4-mediated metastasis of pancreatic cancer cells
por: Senapati, Shantibhusan, et al.
Publicado: (2011)

Expression of MUC-2, MUC-6, NAPE-PLD, IL-6 and IL-13 in Healthy and Metaplastic Bronchial Epithelium
por: Lohova, Elizabeta, et al.
Publicado: (2022)

Altered Mucins (MUC) Trafficking in Benign and Malignant Conditions
por: Joshi, Suhasini, et al.
Publicado: (2014)

Helicobacter pylori Chronic Infection Selects for Effective Colonizers of Metaplastic Glands
por: O’Brien, V. P., et al.
Publicado: (2023)

Altered Expression of Transmembrane Mucins, MUC1 and MUC4, in Bladder Cancer: Pathological Implications in Diagnosis
por: Kaur, Sukhwinder, et al.
Publicado: (2014)

MicroRNA-200c Modulates the Expression of MUC4 and MUC16 by Directly Targeting Their Coding Sequences in Human Pancreatic Cancer
por: Radhakrishnan, Prakash, et al.
Publicado: (2013)

Characterization of recombinant β subunit of human MUC4 mucin (rMUC4β)
por: Kshirsagar, Prakash G., et al.
Publicado: (2021)

PAF1 cooperates with YAP1 in metaplastic ducts to promote pancreatic cancer
por: Nimmakayala, Rama Krishna, et al.
Publicado: (2022)

MUC4 and MUC1 Expression in Adenocarcinoma of the Stomach Correlates with Vessel Invasion and Lymph Node Metastasis: An Immunohistochemical Study of Early Gastric Cancer
por: Tamura, Yukihiro, et al.
Publicado: (2012)

MUC4 stabilizes HER2 expression and maintains the cancer stem cell population in ovarian cancer cells
por: Ponnusamy, Moorthy P, et al.
Publicado: (2011)

Roles unveiled for membrane-associated mucins at the ocular surface using a Muc4 knockout mouse model
por: Martinez-Carrasco, Rafael, et al.
Publicado: (2023)

Membrane proximal ectodomain cleavage of MUC16 occurs in the acidifying Golgi/post-Golgi compartments
por: Das, Srustidhar, et al.
Publicado: (2015)

Uncovering and characterizing splice variants associated with survival in lung cancer patients
por: West, Sean, et al.
Publicado: (2019)

Differences in MUC4 Expression in Pancreatic Cancers and Pancreatic Cysts in Egypt
por: Etekpo, Asserewou, et al.
Publicado: (2018)

Synaptic Plasticity, Metaplasticity and Depression
por: Vose, Linnea R., et al.
Publicado: (2017)

Pathobiological Implications of MUC16 Expression in Pancreatic Cancer
por: Haridas, Dhanya, et al.
Publicado: (2011)

Aberrant methylation of MUC1 and MUC4 promoters are potential prognostic biomarkers for pancreatic ductal adenocarcinomas
por: Yokoyama, Seiya, et al.
Publicado: (2016)

Monoclonal Antibodies Recognizing the Non-Tandem Repeat Regions of the Human Mucin MUC4 in Pancreatic Cancer
por: Jain, Maneesh, et al.
Publicado: (2011)

Imaging Findings of Metaplastic Carcinoma of the Breast with Pathologic Correlation
por: Donato, Henrique, et al.
Publicado: (2018)

Neurogranin Regulates Metaplasticity
por: Zhong, Ling, et al.
Publicado: (2020)

Amphiphilic polyanhydride-based recombinant MUC4β-nanovaccine activates dendritic cells
por: Banerjee, Kasturi, et al.
Publicado: (2019)

Transcriptomic alterations underlying metaplasia into specific metaplastic components in metaplastic breast carcinoma
por: Lien, Huang-Chun, et al.
Publicado: (2023)

Metaplastic breast cancer with chondroid differentiation
por: Myint, Zin W., et al.
Publicado: (2015)

MUC4 and MUC5AC are highly specific tumour-associated mucins in biliary tract cancer
por: Matull, W R, et al.
Publicado: (2008)

MUC16 contributes to the metastasis of pancreatic ductal adenocarcinoma through focal adhesion mediated signaling mechanism
por: Muniyan, Sakthivel, et al.
Publicado: (2016)

MUC16-mediated activation of mTOR and c-MYC reprograms pancreatic cancer metabolism
por: Shukla, Surendra K., et al.
Publicado: (2015)

Pancreatic cancer cells resistance to gemcitabine: the role of MUC4 mucin
por: Bafna, S, et al.
Publicado: (2009)

Targeting EGF-receptor(s) - STAT1 axis attenuates tumor growth and metastasis through downregulation of MUC4 mucin in human pancreatic cancer
por: Seshacharyulu, Parthasarathy, et al.
Publicado: (2014)

Novel HER3/MUC4 oncogenic signaling aggravates the tumorigenic phenotypes of pancreatic cancer cells
por: Lakshmanan, Imayavaramban, et al.
Publicado: (2015)

Metaplastic carcinoma of the breast: an immunohistochemical study
por: Altaf, Fadwa J, et al.
Publicado: (2014)

MUC16 and TP53 family co-regulate tumor-stromal heterogeneity in pancreatic adenocarcinoma
por: Chirravuri-Venkata, Ramakanth, et al.
Publicado: (2023)

Nicotine, IFN-γ and retinoic acid mediated induction of MUC4 in pancreatic cancer requires E2F1 and STAT-1 transcription factors and utilize different signaling cascades
por: Kunigal, Sateesh, et al.
Publicado: (2012)

Expression of MUC17 Is Regulated by HIF1α-Mediated Hypoxic Responses and Requires a Methylation-Free Hypoxia Responsible Element in Pancreatic Cancer
por: Kitamoto, Sho, et al.
Publicado: (2012)

CytoML for cross‐platform cytometry data sharing
por: Finak, Greg, et al.
Publicado: (2018)

Depletion of transmembrane mucin 4 (Muc4) alters intestinal homeostasis in a genetically engineered mouse model of colorectal cancer
por: Pothuraju, Ramesh, et al.
Publicado: (2022)

Nicotine/Cigarette-smoke Promotes Metastasis of Pancreatic Cancer Through α7nAChR-mediated MUC4 Up-regulation
por: Momi, Navneet, et al.
Publicado: (2012)

The metaplastic mosaic of Barrett’s oesophagus
por: Biswas, Sujata, et al.
Publicado: (2018)

Molecular implications of MUC5AC-CD44 axis in colorectal cancer progression and chemoresistance
por: Pothuraju, Ramesh, et al.
Publicado: (2020)

MUC4 Overexpression Augments Cell Migration and Metastasis through EGFR Family Proteins in Triple Negative Breast Cancer Cells
por: Mukhopadhyay, Partha, et al.
Publicado: (2013)

Pathobiological Implications of Mucin (MUC) Expression in the Outcome of Small Bowel Cancer
por: Shibahara, Hiroaki, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_a5n2pl28b5rtvecn5j3f4qga9m