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Specific Uptake in the Bone Marrow Causes High Absorbed Red Marrow Doses During [(177)Lu]Lu-DOTATATE Treatment

Bone marrow suppression is a common side effect after [(177)Lu]Lu-DOTATATE treatment of neuroendocrine neoplasms. Neuroendocrine neoplasms share expression of somatostatin receptor type 2 with CD34-positive hematopoietic progenitor cells, potentially leading to active uptake in the radiosensitive re...

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Detalles Bibliográficos
Autores principales: Hemmingsson, Jens, Svensson, Johanna, Hallqvist, Andreas, Smits, Katja, Johanson, Viktor, Bernhardt, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society of Nuclear Medicine 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10478826/
https://www.ncbi.nlm.nih.gov/pubmed/37290797
http://dx.doi.org/10.2967/jnumed.123.265484