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Prodromal Parkinson disease signs are predicted by a whole-blood inflammatory transcriptional signature in young Pink1−/− rats

BACKGROUND: Parkinson disease (PD) is the fastest growing neurodegenerative disease. The molecular pathology of PD in the prodromal phase is poorly understood; as such, there are no specific prognostic or diagnostic tests. A validated Pink1 genetic knockout rat was used to model early-onset and prog...

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Detalles Bibliográficos
Autores principales: Lechner, Sarah A., Barnett, David G.S., Gammie, Stephen C., Kelm-Nelson, Cynthia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10479403/
https://www.ncbi.nlm.nih.gov/pubmed/37674708
http://dx.doi.org/10.21203/rs.3.rs-3269607/v1